Canine Health Markers 5-in-1 Combo Test Kit (cPL/CG/CysC/cNT-proBNP/cTIgE)

Canine pancreatic lipase (cPL) is an enzyme produced by the pancreas in dogs. Pancreatitis, an inflammatory condition of the pancreas, is generally divided into acute pancreatitis and chronic pancreatitis. Acute pancreatitis is characterized by neutrophil infiltration, pancreatic necrosis, peripancreatic fat necrosis, edema, and tissue injury. Chronic pancreatitis is characterized by pancreatic fibrosis and atrophy. Compared with acute pancreatitis, chronic pancreatitis is usually less acutely harmful but occurs more frequently. When a dog has pancreatitis, the pancreas is damaged, leading to a rapid increase in the levels of canine pancreatic lipase in the blood. Currently, pancreatic lipase is one of the best specific indicators for the diagnosis of canine pancreatitis.

Cholyglycine (CG) is one of the conjugated bile acids formed by the combination of cholic acid and glycine. Cholyglycine serves as the primary bile acid component of serum during the late trimester of pregnancy. When hepatocytes are damaged, their capacity to metabolize CG diminishes, leading to an increased CG level in the blood. When bile stagnation occurs, the liver fails to excrete bile acid, causing an increased level of CG that refluxes into the circulation, thereby raising the blood CG level.

Cystatin C is one of the cysteine protease inhibitor proteins. CysC is an endogenous substance that has basically met the requirements of ideal endogenous GFR markers so far. It is a newly developed indicator with good sensitivity and high specificity for evaluating dogs kidney function. 

Reference Recommendations for NEW-TEST Canine NT-proBNP: When a dog has valvular disease (MMVD), a concentration of 800-2500 nmol/L suggests that the dog's MMVD may be in the b1-b2 stage. Most dogs may show no obvious symptoms. A concentration of 2500-4500 nmol/L (b2-C stage) indicates that the dog has a high risk of developing heart failure (HF) within 6-12 months. It is recommended to perform further echocardiogram examinations or annual physical examinations. When the concentration is > 4500 nmol/L, the likelihood of heart failure is extremely high.

Canine Total IgE is a class of immunoglobulin (Ig) with a molecular weight of 188kD, which has a lower level in serum. It is commonly used in the diagnosis of allergic reactions and can also assist in the diagnosis of parasitic infections and multiple myeloma.

1. Allergic reactions: When an allergic reaction occurs, it results in the rise of allergen lgE. The higher the allergen lgE is, the more severe the reaction is.

2. Parasitic infections: When the pet is infected by parasites, the allergen lgE may also be elevated, which is generally related to the mild allergy caused by the protein of the parasites. In addition, the report shows tumors may also caused the elevation of total IgE.