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Feline Renal Function Markers 3-in-1 Combo Test Kit (SDMA/Crea/CysC)
Detection Purpose
Symmetric dimethylarginine (SDMA)is a by-product of kidney metabolism and can be utilized as a biomarker for renal function. The SDMA level in the blood can indicate the function status of the kidney. Compared with creatinine testing results, SDMA can detect kidney function diseases such as acute kidney injury (AKI) and chronic kidney disease (CKD) at an earlier stage.
Cystatin C (CysC) is a cysteine protease inhibitor that is widely present in nucleated cells of various tissues and body fluids. Circulating cystatin C is exclusively cleared by glomerular filtration, making it an endogenous marker that reflects changes in the glomerular filtration rate (GFR). It is reabsorbed in the proximal tubules but is completely metabolized and broken down after reabsorption, without re-entering the bloodstream. Therefore, its blood concentration is determined by the glomerular filtration rate and is not influenced by any external factors, making it an ideal endogenous marker for reflecting changes in GFR.
Creatinine (Crea) is a compound produced during the process of energy generation in muscles, formed through the metabolism of phosphocreatine. Normal kidney function can filter and excrete creatinine from the blood. Elevated blood creatinine levels are commonly seen in conditions such as kidney disease, high-protein diets, or intense physical exercise, and serve as an indicator of reduced glomerular filtration function.
Detection Principle
SDMA/Crea:
This product utilizes fluorescence immunochromatography to quantitatively detect the SDMA, CysC and Crea content in cat’s blood. The basic principle is as follows: T and C lines are respectively marked on the nitrocellulose membrane.The T line is coated with SDMA or Crea antigen a. The binding pad is sprayed with another fluorescent nano-material-labeled antibody b that specifically recognize SDMA or Crea. The SDMAin the sample first combines with the nano-material-labeled antibody b to form a complex. Then, through chromatography, the complex moves upward to competes with SDMA on the T line, When the test strip is irradiated by excitation light, the nanomaterial emits a fluorescent signal, and the intensity of this signal is negatively correlated with the concentration of antigen in the sample.
CysC:
This product utilizes double-antibody sandwich method. The basic principle: T and C lines are respectively marked on the nitrocellulose membrane. The T line is coated with CysC antibody a. The binding pad is sprayed with another fluorescent nano-material-labeled antibody b that specifically recognizes CysC. The CysC in the sample first combines with the nano-material-labeled antibody b to form a complex. Then, through chromatography. This complex is subsequently captured by antibody a. When the test strip is irradiated by excitation light, the nanomaterial emits a fluorescent signal, and the intensity of this signal is positively correlated with the concentration of antigen in the sample.
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